Myoung Hwa Lee, Daniel P Perl, Joseph Steiner, Nicholas Pasternack, Wenxue Li, Dragan Maric, Farinaz Safavi, Iren Horkayne-Szakaly, Robert Jones, Michelle N Stram, Joel T Moncur, Marco Hefti, Rebecca D Folkerth, Avindra Nath, Neurovascular injury with complement activation and inflammation in COVID-19, Brain, Volume 145, Issue 7, July 2022, Pages 2555–2568, doi.org/10.1093/brain/awac151
Quote:
Injury to the microvasculature by immune complexes with complement activation is the key central event that results in breakdown of the blood–brain barrier, microthromboses, perivascular inflammation and neuronal injury.
Interpretation notes:
- “Microthromboses” means “mini-strokes”.
- “Breakdown of the blood-brain barrier” is bad news.
- “Neuronal injury” means damage to brain cells per se.