Avoid The Plague / Research

SARS-CoV-2 Selectively Induces the Expression of Unproductive Splicing Isoforms of Interferon, Class I MHC, and Splicing Machinery Genes
publication, vol 25, 23 May 2024
Dias, Thomaz L.; Mamede, Izabela; de Toledo, Nayara E., et al

Quote

We postulate that SARS-CoV-2 employs an unreported tactic of exploiting the host splicing machinery to bolster viral replication and subvert the immune response by selectively upregulating unproductive splicing isoforms from antigen presentation and antiviral response genes.

Unlike other coronaviruses and viruses known to interfere with host splicing machinery, … SARS-CoV-2 uniquely blocks interferon (IFN) expression and modulates specific immune cell populations

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